Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors. (Record no. 24358907)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03152 a2200961 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250517002815.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201504s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1520-4804 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1021/jm5013352 |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Pasquier, Benoit |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20150427 |
| 245 00 - TITLE STATEMENT | |
| Title | Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Journal of medicinal chemistry |
| Date of publication, distribution, etc. | Jan 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 376-400 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Amino Acid Sequence |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Antineoplastic Agents |
| General subdivision | chemistry |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Area Under Curve |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Bridged Bicyclo Compounds, Heterocyclic |
| General subdivision | chemistry |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Caco-2 Cells |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cell Line, Tumor |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Class III Phosphatidylinositol 3-Kinases |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Crystallography, X-Ray |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drug Discovery |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Enzyme Inhibitors |
| General subdivision | chemistry |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | HeLa Cells |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Humans |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Male |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice, SCID |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Models, Chemical |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Models, Molecular |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Molecular Sequence Data |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Molecular Structure |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Neoplasms |
| General subdivision | drug therapy |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Protein Binding |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Protein Structure, Tertiary |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pyrimidinones |
| General subdivision | chemistry |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Rats, Sprague-Dawley |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Sequence Homology, Amino Acid |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Thermodynamics |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Xenograft Model Antitumor Assays |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | El-Ahmad, Youssef |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Filoche-Rommé, Bruno |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dureuil, Christine |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fassy, Florence |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abecassis, Pierre-Yves |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mathieu, Magali |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bertrand, Thomas |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Benard, Tsiala |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Barrière, Cédric |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | El Batti, Samira |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Letallec, Jean-Philippe |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sonnefraud, Véronique |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Brollo, Maurice |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Delbarre, Laurence |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Loyau, Véronique |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pilorge, Fabienne |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bertin, Luc |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Richepin, Patrick |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Arigon, Jérôme |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Labrosse, Jean-Robert |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Clément, Jacques |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Durand, Florence |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Combet, Romain |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Perraut, Pierre |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Leroy, Vincent |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gay, Frédéric |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lefrançois, Dominique |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bretin, François |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marquette, Jean-Pierre |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Michot, Nadine |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Caron, Anne |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Castell, Christelle |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Schio, Laurent |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | McCort, Gary |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Goulaouic, Hélène |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Garcia-Echeverria, Carlos |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ronan, Baptiste |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of medicinal chemistry |
| Related parts | vol. 58 |
| -- | no. 1 |
| -- | p. 376-400 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1021/jm5013352">https://doi.org/10.1021/jm5013352</a> |
| Public note | Available from publisher's website |
No items available.