Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy. (Record no. 24077279)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02393 a2200721 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250516225432.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201412s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1520-4804 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1021/jm500916t |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Voight, Eric A |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20141203 |
| 245 00 - TITLE STATEMENT | |
| Title | Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Journal of medicinal chemistry |
| Date of publication, distribution, etc. | Sep 2014 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 7412-24 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article; Research Support, Non-U.S. Gov't |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Analgesics |
| General subdivision | chemistry |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Area Under Curve |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Body Temperature |
| General subdivision | drug effects |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Dogs |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Dose-Response Relationship, Drug |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drug Discovery |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | HEK293 Cells |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Humans |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Isoquinolines |
| General subdivision | chemistry |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Metabolic Clearance Rate |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Models, Chemical |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Molecular Structure |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Rats |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Structure-Activity Relationship |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | TRPV Cation Channels |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Urea |
| General subdivision | analogs & derivatives |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gomtsyan, Arthur R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Daanen, Jerome F |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Perner, Richard J |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Schmidt, Robert G |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bayburt, Erol K |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | DiDomenico, Stanley |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | McDonald, Heath A |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Puttfarcken, Pamela S |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chen, Jun |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Neelands, Torben R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bianchi, Bruce R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Han, Ping |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Reilly, Regina M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Franklin, Pamela H |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Segreti, Jason A |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nelson, Richard A |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Su, Zhi |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | King, Andrew J |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Polakowski, James S |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Baker, Scott J |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gauvin, Donna M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lewis, LaGeisha R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mikusa, Joseph P |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Joshi, Shailen K |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Faltynek, Connie R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kym, Philip R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kort, Michael E |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of medicinal chemistry |
| Related parts | vol. 57 |
| -- | no. 17 |
| -- | p. 7412-24 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1021/jm500916t">https://doi.org/10.1021/jm500916t</a> |
| Public note | Available from publisher's website |
No items available.