Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans. (Record no. 19175896)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02267 a2200661 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250515190056.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201001s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1521-0103 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1124/jpet.109.157909 |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Atack, John R |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20100126 |
| 245 00 - TITLE STATEMENT | |
| Title | Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | The Journal of pharmacology and experimental therapeutics |
| Date of publication, distribution, etc. | Jan 2010 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 17-25 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article; Research Support, Non-U.S. Gov't |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Binding Sites |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Brain |
| General subdivision | drug effects |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Dose-Response Relationship, Drug |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Flumazenil |
| General subdivision | pharmacology |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | GABA Agonists |
| General subdivision | blood |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | GABA-A Receptor Agonists |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | GABA-A Receptor Antagonists |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Humans |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Macaca mulatta |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Papio |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Positron-Emission Tomography |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Protein Binding |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Protein Subunits |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pyridazines |
| General subdivision | blood |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Radioligand Assay |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Rats |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Species Specificity |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Tissue Distribution |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Triazoles |
| General subdivision | blood |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wong, Dean F |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fryer, Tim D |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ryan, Christine |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sanabria, Sandra |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhou, Yun |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dannals, Robert F |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Eng, Wai-si |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gibson, Raymond E |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Burns, H Donald |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Vega, Jose M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Vessy, Laura |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Scott-Stevens, Paul |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Beech, John S |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Baron, Jean-Claude |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sohal, Bindi |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Schrag, Michael L |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aigbirhio, Franklin I |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | McKernan, Ruth M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hargreaves, Richard J |
| 773 0# - HOST ITEM ENTRY | |
| Title | The Journal of pharmacology and experimental therapeutics |
| Related parts | vol. 332 |
| -- | no. 1 |
| -- | p. 17-25 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1124/jpet.109.157909">https://doi.org/10.1124/jpet.109.157909</a> |
| Public note | Available from publisher's website |
No items available.