Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease. (Record no. 18469580)
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|---|---|
| fixed length control field | 02907 a2200949 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250515145945.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200904s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1520-4804 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1021/jm801252w |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mayer, Scott C |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20090403 |
| 245 00 - TITLE STATEMENT | |
| Title | Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Journal of medicinal chemistry |
| Date of publication, distribution, etc. | Dec 2008 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 7348-51 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Alzheimer Disease |
| General subdivision | drug therapy |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Amyloid Precursor Protein Secretases |
| General subdivision | antagonists & inhibitors |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Amyloid beta-Peptides |
| General subdivision | metabolism |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Crystallography, X-Ray |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Disease Models, Animal |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Dose-Response Relationship, Drug |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drug Discovery |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Enzyme Inhibitors |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice, Transgenic |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Models, Molecular |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Molecular Conformation |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Receptor, Notch1 |
| General subdivision | metabolism |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Stereoisomerism |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Structure-Activity Relationship |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Sulfonamides |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Thiophenes |
| General subdivision | chemical synthesis |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kreft, Anthony F |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Harrison, Boyd |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abou-Gharbia, Magid |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Antane, Madelene |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aschmies, Suzan |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Atchison, Kevin |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chlenov, Michael |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Cole, Derek C |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Comery, Thomas |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Diamantidis, George |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ellingboe, John |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fan, Kristi |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Galante, Rocco |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gonzales, Cathleen |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ho, Douglas M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hoke, Molly E |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hu, Yun |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Huryn, Donna |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jain, Uday |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jin, Mei |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kremer, Kenneth |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kubrak, Dennis |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lin, Melissa |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lu, Peimin |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magolda, Ron |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Martone, Robert |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Moore, William |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Oganesian, Aram |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pangalos, Menelas N |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Porte, Alex |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Reinhart, Peter |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Resnick, Lynn |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Riddell, David R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sonnenberg-Reines, June |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Stock, Joseph R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sun, Shaiu-Ching |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wagner, Erik |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wang, Ting |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Woller, Kevin |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Xu, Zheng |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zaleska, Margaret M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zeldis, Joseph |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhang, Minsheng |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zhou, Hua |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jacobsen, J Steven |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of medicinal chemistry |
| Related parts | vol. 51 |
| -- | no. 23 |
| -- | p. 7348-51 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1021/jm801252w">https://doi.org/10.1021/jm801252w</a> |
| Public note | Available from publisher's website |
No items available.