Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity. (Record no. 17607950)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02184 a2200661 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250515100858.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200804s 0 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 0022-2623 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1021/jm0709034 |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | NLM |
| Language of cataloging | eng |
| Transcribing agency | NLM |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Smith, Brian M |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 20080417 |
| 245 00 - TITLE STATEMENT | |
| Title | Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity. |
| Medium | [electronic resource] |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Journal of medicinal chemistry |
| Date of publication, distribution, etc. | Jan 2008 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 305-13 p. |
| Other physical details | digital |
| 500 ## - GENERAL NOTE | |
| General note | Publication Type: Journal Article |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Animals |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Anti-Obesity Agents |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Benzazepines |
| General subdivision | chemical synthesis |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cell Line |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Eating |
| General subdivision | drug effects |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Humans |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Inositol 1,4,5-Trisphosphate |
| General subdivision | metabolism |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Male |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Obesity |
| General subdivision | drug therapy |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Rats |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Rats, Sprague-Dawley |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Serotonin 5-HT2 Receptor Agonists |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Stereoisomerism |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Structure-Activity Relationship |
| 650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Weight Gain |
| General subdivision | drug effects |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Smith, Jeffrey M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tsai, James H |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Schultz, Jeffrey A |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gilson, Charles A |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Estrada, Scott A |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chen, Rita R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Park, Douglas M |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Prieto, Emily B |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gallardo, Charlemagne S |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sengupta, Dipanjan |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dosa, Peter I |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Covel, Jon A |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ren, Albert |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Webb, Robert R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Beeley, Nigel R A |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Martin, Michael |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Morgan, Michael |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Espitia, Stephen |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Saldana, Hazel R |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bjenning, Christina |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Whelan, Kevin T |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Grottick, Andrew J |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Menzaghi, Frederique |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Thomsen, William J |
| 773 0# - HOST ITEM ENTRY | |
| Title | Journal of medicinal chemistry |
| Related parts | vol. 51 |
| -- | no. 2 |
| -- | p. 305-13 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1021/jm0709034">https://doi.org/10.1021/jm0709034</a> |
| Public note | Available from publisher's website |
No items available.