Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part II: Mechanism-based inhibition of rat liver microsome-mediated aflatoxin B1-DNA binding by the candidate antimutagen 7,8-diacetoxy-4-methylcoumarin.

Raj, H G

Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part II: Mechanism-based inhibition of rat liver microsome-mediated aflatoxin B1-DNA binding by the candidate antimutagen 7,8-diacetoxy-4-methylcoumarin. [electronic resource] - Bioorganic & medicinal chemistry Oct 1998 - 1895-904 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0968-0896

10.1016/s0968-0896(98)00111-4 doi


7-Alkoxycoumarin O-Dealkylase--metabolism
Aflatoxin B1--metabolism
Animals
Antimutagenic Agents--pharmacology
Biotransformation
Bone Marrow Cells--drug effects
Coumarins--metabolism
Cytochrome P-450 CYP1A1--metabolism
DNA--drug effects
Dietary Supplements
Male
Micronucleus Tests
Microsomes, Liver--drug effects
Mutagens--metabolism
Rats
Time Factors