Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation.

Gerber, H P

Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. [electronic resource] - The Journal of biological chemistry Nov 1998 - 30336-43 p. digital

Publication Type: Journal Article

0021-9258

10.1074/jbc.273.46.30336 doi


Amino Acid Chloromethyl Ketones--pharmacology
Apoptosis
Cell Survival
Cells, Cultured
Cysteine Proteinase Inhibitors--pharmacology
Endothelial Growth Factors--genetics
Endothelium, Vascular--cytology
Enzyme Activation
Fibroblast Growth Factor 2--physiology
Humans
Lymphokines--genetics
Mutagenesis, Site-Directed
Phosphatidylinositol 3-Kinases--metabolism
Phosphorylation
Protein Serine-Threonine Kinases--metabolism
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-akt
Receptor Protein-Tyrosine Kinases--metabolism
Receptors, Growth Factor--metabolism
Receptors, Vascular Endothelial Growth Factor
Signal Transduction
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factors