The antiproliferative and cell cycle effects of 5,6,7, 8-tetrahydro-N5,N10-carbonylfolic acid, an inhibitor of methylenetetrahydrofolate dehydrogenase, are potentiated by hypoxanthine.

Tonkinson, J L

The antiproliferative and cell cycle effects of 5,6,7, 8-tetrahydro-N5,N10-carbonylfolic acid, an inhibitor of methylenetetrahydrofolate dehydrogenase, are potentiated by hypoxanthine. [electronic resource] - The Journal of pharmacology and experimental therapeutics Oct 1998 - 315-21 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-3565


Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Cycle--drug effects
Cell Division--drug effects
Deoxyadenine Nucleotides--metabolism
Drug Synergism
Enzyme Inhibitors--pharmacology
Folic Acid--analogs & derivatives
Humans
Hypoxanthine--pharmacology
Methylenetetrahydrofolate Dehydrogenase (NADP)--antagonists & inhibitors
Thymine Nucleotides--metabolism
Tumor Cells, Cultured