The mechanism of inhibition of topoisomerase IV by quinolone antibacterials.

Khodursky, A B

The mechanism of inhibition of topoisomerase IV by quinolone antibacterials. [electronic resource] - The Journal of biological chemistry Oct 1998 - 27668-77 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

0021-9258

10.1074/jbc.273.42.27668 doi


Adenosine Triphosphatases--genetics
Anti-Infective Agents--pharmacology
Chromosomes, Bacterial--drug effects
DNA Adducts
DNA Damage
DNA Helicases
DNA Repair--drug effects
DNA Replication--drug effects
DNA Topoisomerase IV
DNA Topoisomerases, Type II--drug effects
Escherichia coli--drug effects
Escherichia coli Proteins
Exodeoxyribonuclease V
Exodeoxyribonucleases--genetics
Models, Genetic
Mutation
Norfloxacin--pharmacology
Plasmids--biosynthesis
Protein Binding
Rec A Recombinases--genetics
SOS Response, Genetics
Topoisomerase II Inhibitors