CD4(+) T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand (CD40L:CD154) antibody lose their graft-versus-host disease lethality capacity but retain nominal antigen responses.

Blazar, B R

CD4(+) T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand (CD40L:CD154) antibody lose their graft-versus-host disease lethality capacity but retain nominal antigen responses. [electronic resource] - The Journal of clinical investigation Aug 1998 - 473-82 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0021-9738

10.1172/JCI3741 doi


Animals
Antibodies, Monoclonal--immunology
CD4-Positive T-Lymphocytes--drug effects
CD40 Antigens--immunology
CD40 Ligand
Cells, Cultured
Graft vs Host Disease--immunology
Immunosuppression Therapy
Interleukin-2--pharmacology
Isoantigens--immunology
Lymphocyte Culture Test, Mixed
Membrane Glycoproteins--antagonists & inhibitors
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, SCID
Specific Pathogen-Free Organisms