Nonredox 5-lipoxygenase inhibitors require glutathione peroxidase for efficient inhibition of 5-lipoxygenase activity.

Werz, O

Nonredox 5-lipoxygenase inhibitors require glutathione peroxidase for efficient inhibition of 5-lipoxygenase activity. [electronic resource] - Molecular pharmacology Aug 1998 - 445-51 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0026-895X

10.1124/mol.54.2.445 doi


Arachidonate 5-Lipoxygenase--metabolism
Bridged Bicyclo Compounds--pharmacology
Cells, Cultured--drug effects
Enzyme Activation
Escherichia coli--genetics
Glutathione Peroxidase--metabolism
Humans
Hydrogen Peroxide--metabolism
Lipoxygenase Inhibitors--pharmacology
Oxidation-Reduction
Oxidative Stress--drug effects
Peroxidase--antagonists & inhibitors
Pyrans--pharmacology
Quinolines--pharmacology
Quinolones--pharmacology
Selenium--metabolism
Sulfhydryl Compounds--metabolism