2'-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain.

Ruckman, J

2'-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain. [electronic resource] - The Journal of biological chemistry Aug 1998 - 20556-67 p. digital

Publication Type: Journal Article

0021-9258

10.1074/jbc.273.32.20556 doi


Amino Acid Sequence
Animals
Capillary Permeability--drug effects
Cells, Cultured
Cross-Linking Reagents--metabolism
Endothelial Growth Factors--metabolism
Endothelium, Vascular--drug effects
Fluorine Compounds--chemistry
Ligands
Lymphokines--metabolism
Molecular Sequence Data
Muscle, Smooth, Vascular
Neovascularization, Physiologic--drug effects
Oligoribonucleotides--chemistry
Protein Binding--drug effects
Proteins--metabolism
RNA--chemistry
RNA-Binding Proteins--metabolism
Receptor Protein-Tyrosine Kinases--metabolism
Receptors, Growth Factor--metabolism
Receptors, Vascular Endothelial Growth Factor
Recombinant Proteins--metabolism
Swine
Transfection--genetics
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors