Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase.

Jackson, D S

Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase. [electronic resource] - Journal of medicinal chemistry Jun 1998 - 2289-301 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0022-2623

10.1021/jm970543s doi


Amino Acids--chemical synthesis
Animals
Cattle
Chymases
Granzymes
Humans
Kinetics
Mast Cells--enzymology
Oligopeptides--chemical synthesis
Organophosphonates--chemical synthesis
Rats
Serine Endopeptidases--metabolism
Serine Proteinase Inhibitors--chemical synthesis
Structure-Activity Relationship
T-Lymphocytes, Cytotoxic--enzymology
Trypsin--metabolism
Trypsin Inhibitors--chemical synthesis
Tryptases