Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes.

Amacher, D E

Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes. [electronic resource] - Toxicology letters Jan 1998 - 115-25 p. digital

Publication Type: Comparative Study; Journal Article

0378-4274

10.1016/s0378-4274(97)00108-2 doi


Animals
Antibodies--immunology
Aryl Hydrocarbon Hydroxylases
Biomarkers--analysis
Clofibrate--pharmacology
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System--biosynthesis
Dexamethasone--pharmacology
Enzyme Induction--drug effects
Enzyme Inhibitors--pharmacology
Ethylmorphine-N-Demethylase--antagonists & inhibitors
Female
Isoniazid--pharmacology
Male
Microsomes, Liver--drug effects
Oxidoreductases, N-Demethylating--antagonists & inhibitors
Phenobarbital--pharmacology
Pregnenolone Carbonitrile--pharmacology
Rats
Rats, Sprague-Dawley
Sensitivity and Specificity
Sex Factors
beta-Naphthoflavone--pharmacology