Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.

Moreau, P

Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle. [electronic resource] - Journal of medicinal chemistry May 1998 - 1631-40 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-2623

10.1021/jm970843+ doi


Aminoglycosides
Animals
Anti-Bacterial Agents--chemical synthesis
Anti-HIV Agents--chemical synthesis
Antibiotics, Antineoplastic--chemical synthesis
Bacillus cereus--drug effects
Candida albicans--drug effects
Carbazoles
DNA--drug effects
DNA Topoisomerases, Type I--metabolism
Drug Screening Assays, Antitumor
Enzyme Inhibitors--chemical synthesis
Escherichia coli--drug effects
HIV-1--drug effects
Indoles--chemical synthesis
Mice
Microbial Sensitivity Tests
Protein Kinase C--antagonists & inhibitors
Streptomyces--drug effects
Structure-Activity Relationship
Topoisomerase I Inhibitors
Tumor Cells, Cultured