p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells.

Brugarolas, J

p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells. [electronic resource] - The Journal of cell biology Apr 1998 - 503-14 p. digital

Publication Type: Journal Article

0021-9525

10.1083/jcb.141.2.503 doi


Animals
Blood
CDC2-CDC28 Kinases
Cell Adhesion
Cell Communication
Cell Cycle--physiology
Cell Cycle Proteins
Cell Division
Cell Size
Cell Transformation, Neoplastic
Cells, Cultured
Cyclin D1--analysis
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinases--antagonists & inhibitors
Cyclins--genetics
Enzyme Inhibitors
Fibroblasts--cytology
G1 Phase--genetics
Mice
Mice, Knockout
Mice, Nude
Microtubule-Associated Proteins--analysis
Mutation
Neoplasms, Experimental--etiology
Protein Serine-Threonine Kinases--antagonists & inhibitors
Proto-Oncogene Proteins
Retinoblastoma Protein--genetics
Signal Transduction--physiology
Tumor Suppressor Proteins