Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4 -hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption.

Rosenblum, S B

Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4 -hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption. [electronic resource] - Journal of medicinal chemistry Mar 1998 - 973-80 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm970701f doi


Animals
Anticholesteremic Agents--chemistry
Azetidines--chemistry
Cholesterol--administration & dosage
Cricetinae
Drug Design
Ezetimibe
Liver--drug effects
Structure-Activity Relationship