Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites.

Urbatsch, I L

Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites. [electronic resource] - Biochemistry Mar 1998 - 4592-602 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0006-2960

10.1021/bi9728001 doi


ATP Binding Cassette Transporter, Subfamily B
ATP Binding Cassette Transporter, Subfamily B, Member 1--biosynthesis
ATP-Binding Cassette Transporters--biosynthesis
Adenosine Triphosphatases--metabolism
Adenosine Triphosphate--analogs & derivatives
Affinity Labels--metabolism
Azides--metabolism
Base Sequence
Binding Sites
Enzyme Inhibitors--pharmacology
Escherichia coli--metabolism
Hydrolysis
Lipid Metabolism
Mutagenesis, Site-Directed
Nucleotides--metabolism
Pichia--metabolism
Point Mutation
Vanadates--pharmacology