alpha-Substituted malonester amides: tools to define the relationship between ACAT inhibition and adrenal toxicity.
Sliskovic, D R
alpha-Substituted malonester amides: tools to define the relationship between ACAT inhibition and adrenal toxicity. [electronic resource] - Journal of medicinal chemistry Feb 1998 - 682-90 p. digital
Publication Type: Comparative Study; Journal Article
0022-2623
10.1021/jm970560h doi
Adrenal Glands--drug effects
Amides--pharmacology
Animals
Anticholesteremic Agents--chemical synthesis
Biological Availability
Cholesterol--blood
Cholesterol, Dietary--administration & dosage
Chromatography, High Pressure Liquid
Dogs
Enzyme Inhibitors--chemical synthesis
Female
Guinea Pigs
Male
Malonates--chemical synthesis
Mice
Microsomes, Liver--enzymology
Necrosis
Phenylacetates--chemical synthesis
Rats
Rats, Sprague-Dawley
Sterol O-Acyltransferase--antagonists & inhibitors
Tetrazoles--pharmacology
alpha-Substituted malonester amides: tools to define the relationship between ACAT inhibition and adrenal toxicity. [electronic resource] - Journal of medicinal chemistry Feb 1998 - 682-90 p. digital
Publication Type: Comparative Study; Journal Article
0022-2623
10.1021/jm970560h doi
Adrenal Glands--drug effects
Amides--pharmacology
Animals
Anticholesteremic Agents--chemical synthesis
Biological Availability
Cholesterol--blood
Cholesterol, Dietary--administration & dosage
Chromatography, High Pressure Liquid
Dogs
Enzyme Inhibitors--chemical synthesis
Female
Guinea Pigs
Male
Malonates--chemical synthesis
Mice
Microsomes, Liver--enzymology
Necrosis
Phenylacetates--chemical synthesis
Rats
Rats, Sprague-Dawley
Sterol O-Acyltransferase--antagonists & inhibitors
Tetrazoles--pharmacology