Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: synthesis, activity, and modeling.

Barlocco, D

Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: synthesis, activity, and modeling. [electronic resource] - Journal of medicinal chemistry Feb 1998 - 674-81 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-2623

10.1021/jm970427p doi


Abdominal Muscles--physiology
Analgesia
Analgesics, Non-Narcotic--chemical synthesis
Animals
Bridged Bicyclo Compounds, Heterocyclic--chemical synthesis
Cerebral Cortex--metabolism
Humans
Kinetics
Magnetic Resonance Spectroscopy
Male
Mecamylamine--pharmacology
Mice
Models, Molecular
Molecular Conformation
Muscle Contraction--drug effects
Naloxone--pharmacology
Narcotic Antagonists--pharmacology
Pain Threshold--drug effects
Pyridazines--chemical synthesis
Pyridines--chemistry
Rats
Receptors, Cholinergic--drug effects