A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA.

Wei, P

A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. [electronic resource] - Cell Feb 1998 - 451-62 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0092-8674

10.1016/s0092-8674(00)80939-3 doi


3T3 Cells
Amino Acid Sequence
Animals
Bacterial Proteins--genetics
CHO Cells
Cell Nucleus--enzymology
Chemoreceptor Cells
Cloning, Molecular
Cricetinae
Cyclin C
Cyclin T
Cyclin-Dependent Kinases--metabolism
Cyclins--genetics
DNA Footprinting
Escherichia coli Proteins
Gene Expression Regulation, Viral--physiology
Gene Products, tat--metabolism
HIV-1
Humans
Membrane Proteins--genetics
Mice
Molecular Sequence Data
Nucleic Acid Conformation
Positive Transcriptional Elongation Factor B
Protein Serine-Threonine Kinases--metabolism
RNA Polymerase II--metabolism
RNA, Viral--chemistry
Receptors, Cell Surface--genetics
Recombinant Proteins--genetics
Ribonucleases
Substrate Specificity
Transcription, Genetic--physiology
tat Gene Products, Human Immunodeficiency Virus