Renal dysfunction accounts for the dose limiting toxicity of DT390anti-CD3sFv, a potential new recombinant anti-GVHD immunotoxin.

Vallera, D A

Renal dysfunction accounts for the dose limiting toxicity of DT390anti-CD3sFv, a potential new recombinant anti-GVHD immunotoxin. [electronic resource] - Protein engineering Sep 1997 - 1071-6 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0269-2139

10.1093/protein/10.9.1071 doi


Animals
CD3 Complex--toxicity
Diphtheria Toxin--toxicity
Graft vs Host Disease--therapy
Immunoglobulin Fragments--toxicity
Immunotoxins--toxicity
Kidney--drug effects
Liver--drug effects
Macrophages--drug effects
Mice
Mice, Inbred C57BL
Mice, SCID
Recombinant Fusion Proteins--toxicity