Loss of cellular K+ mimics ribotoxic stress. Inhibition of protein synthesis and activation of the stress kinases SEK1/MKK4, stress-activated protein kinase/c-Jun NH2-terminal kinase 1, and p38/HOG1 by palytoxin.

Iordanov, M S

Loss of cellular K+ mimics ribotoxic stress. Inhibition of protein synthesis and activation of the stress kinases SEK1/MKK4, stress-activated protein kinase/c-Jun NH2-terminal kinase 1, and p38/HOG1 by palytoxin. [electronic resource] - The Journal of biological chemistry Feb 1998 - 3528-34 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0021-9258

10.1074/jbc.273.6.3528 doi


Acrylamides--pharmacology
Animals
Cell Line
Cnidarian Venoms
Enzyme Activation
Ion Transport
Potassium--metabolism
Protein Biosynthesis--drug effects
Protein Kinases--genetics
Protein Synthesis Inhibitors--pharmacology
Rats
Ribosomes--drug effects