Site-directed mutagenesis on the m2 muscarinic acetylcholine receptor: the significance of Tyr403 in the binding of agonists and functional coupling.

Vogel, W K

Site-directed mutagenesis on the m2 muscarinic acetylcholine receptor: the significance of Tyr403 in the binding of agonists and functional coupling. [electronic resource] - Molecular pharmacology Dec 1997 - 1087-94 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0026-895X

10.1124/mol.52.6.1087 doi


Acetylcholine--pharmacology
Animals
Binding Sites
CHO Cells
Carbachol--pharmacology
Cricetinae
Cyclic AMP--biosynthesis
GTP-Binding Proteins--physiology
Kinetics
Muscarinic Agonists--metabolism
Muscarinic Antagonists--metabolism
Mutagenesis, Site-Directed
Mutation
Oxotremorine--analogs & derivatives
Receptor, Muscarinic M2
Receptors, Muscarinic--drug effects
Tyrosine--metabolism