Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse.

Kerouz, N J

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. [electronic resource] - The Journal of clinical investigation Dec 1997 - 3164-72 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0021-9738

10.1172/JCI119872 doi


Animals
Blotting, Northern
Humans
Insulin Receptor Substrate Proteins
Insulin Resistance
Intracellular Signaling Peptides and Proteins
Isoenzymes--biosynthesis
Liver--metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Obese
Muscle, Skeletal--metabolism
Obesity--metabolism
Phosphatidylinositol 3-Kinases--biosynthesis
Phosphoproteins--biosynthesis
Phosphorylation
Signal Transduction