Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice.

Colbert, M C

Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice. [electronic resource] - The Journal of clinical investigation Oct 1997 - 1958-68 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0021-9738

10.1172/JCI119727 doi


Animals
Cardiomyopathy, Dilated--genetics
Echocardiography
Female
Gene Dosage
Gene Expression
Gene Targeting--methods
Heart--embryology
Heart Defects, Congenital--genetics
Heart Failure--genetics
Male
Mice
Mice, Transgenic
Myocardium--pathology
Myosin Heavy Chains--genetics
Promoter Regions, Genetic
Receptors, Retinoic Acid--genetics
Ventricular Function, Left