Hypericin-induced apoptosis of human malignant glioma cells is light-dependent, independent of bcl-2 expression, and does not require wild-type p53.

Weller, M

Hypericin-induced apoptosis of human malignant glioma cells is light-dependent, independent of bcl-2 expression, and does not require wild-type p53. [electronic resource] - Neurological research Oct 1997 - 459-70 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0161-6412


Anthracenes
Antibiotics, Antineoplastic--pharmacology
Antineoplastic Agents--pharmacology
Antineoplastic Agents, Hormonal--pharmacology
Apoptosis--physiology
Cell Division--drug effects
Drug Resistance
Glioma--pathology
Humans
Light
Naphthalenes--pharmacology
Perylene--analogs & derivatives
Protein Kinase C--antagonists & inhibitors
Protein Synthesis Inhibitors--pharmacology
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-bcl-2--metabolism
RNA--antagonists & inhibitors
Tamoxifen--pharmacology
Tumor Cells, Cultured--drug effects
Tumor Suppressor Protein p53--physiology
bcl-2-Associated X Protein
fas Receptor--physiology