Geldanamycin, a heat shock protein 90-binding benzoquinone ansamycin, inhibits steroid-dependent translocation of the glucocorticoid receptor from the cytoplasm to the nucleus.

Czar, M J

Geldanamycin, a heat shock protein 90-binding benzoquinone ansamycin, inhibits steroid-dependent translocation of the glucocorticoid receptor from the cytoplasm to the nucleus. [electronic resource] - Biochemistry Jun 1997 - 7776-85 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0006-2960

10.1021/bi970648x doi


Animals
Antibiotics, Antineoplastic--pharmacology
Benzoquinones
Biological Transport
Cell Line
Cell Nucleus--drug effects
Cytoplasm--drug effects
HSP90 Heat-Shock Proteins--metabolism
Lactams, Macrocyclic
Mice
Protein Binding
Quinones--pharmacology
Receptors, Glucocorticoid--metabolism