Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework.

Giardina, G A

Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework. [electronic resource] - Journal of medicinal chemistry Jun 1997 - 1794-807 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm960818o doi


Animals
Binding, Competitive
CHO Cells
Chemical Phenomena
Chemistry, Physical
Cricetinae
Humans
Hydrogen Bonding
Molecular Structure
Muscle Contraction--drug effects
Peptide Fragments--pharmacology
Quinolines--chemical synthesis
Rabbits
Receptors, Neurokinin-3--antagonists & inhibitors
Recombinant Proteins--metabolism
Stereoisomerism
Structure-Activity Relationship
Substance P--analogs & derivatives