A double-blind, placebo-controlled study on the effect of vigabatrin on in vivo parameters of hepatic microsomal enzyme induction and on the kinetics of steroid oral contraceptives in healthy female volunteers.

Bartoli, A

A double-blind, placebo-controlled study on the effect of vigabatrin on in vivo parameters of hepatic microsomal enzyme induction and on the kinetics of steroid oral contraceptives in healthy female volunteers. [electronic resource] - Epilepsia Jun 1997 - 702-7 p. digital

Publication Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

0013-9580

10.1111/j.1528-1157.1997.tb01240.x doi


Adult
Anticonvulsants--pharmacokinetics
Antipyrine--blood
Aryl Hydrocarbon Hydroxylases
Contraceptives, Oral, Combined--blood
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System--drug effects
Double-Blind Method
Drug Interactions
Enzyme Induction--drug effects
Estradiol Congeners--blood
Ethinyl Estradiol--blood
Female
Half-Life
Humans
Levonorgestrel--blood
Microsomes, Liver--drug effects
Oxidoreductases, N-Demethylating--drug effects
Placebos
Vigabatrin
gamma-Aminobutyric Acid--analogs & derivatives
gamma-Glutamyltransferase--blood