Methotrexate pharmacology and resistance in childhood acute lymphoblastic leukemia.

Matherly, L H

Methotrexate pharmacology and resistance in childhood acute lymphoblastic leukemia. [electronic resource] - Leukemia & lymphoma May 1996 - 359-68 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review

1042-8194

10.3109/10428199609093433 doi


Adult
Antimetabolites, Antineoplastic--pharmacokinetics
Biological Transport
Biotransformation
Carrier Proteins--metabolism
Child
Chromosomes, Human, Pair 21--genetics
Disease Susceptibility
Disease-Free Survival
Down Syndrome--complications
Drug Resistance, Neoplasm
Folic Acid Antagonists--pharmacokinetics
Half-Life
Humans
Membrane Proteins
Membrane Transport Proteins
Methotrexate--pharmacokinetics
Neoplasm Proteins--metabolism
Neoplastic Stem Cells--metabolism
Polyglutamic Acid--metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma--drug therapy
Prognosis
Reduced Folate Carrier Protein
Remission Induction
Tetrahydrofolate Dehydrogenase--metabolism