Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
Franchetti, P
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin. [electronic resource] - Journal of medicinal chemistry May 1997 - 1731-7 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
0022-2623
10.1021/jm960864o doi
Animals
Antineoplastic Agents--chemical synthesis
Cell Division--drug effects
Computer Simulation
Crystallography, X-Ray
Enzyme Inhibitors--chemical synthesis
Guanosine Triphosphate--metabolism
Humans
IMP Dehydrogenase--antagonists & inhibitors
Inosine Monophosphate--metabolism
Leukemia--pathology
Lymphoma--pathology
Magnetic Resonance Spectroscopy
Mice
Models, Molecular
Molecular Structure
Neoplasms--pathology
Organoselenium Compounds--chemical synthesis
Ribavirin--analogs & derivatives
Ribonucleosides--chemical synthesis
Tumor Cells, Cultured
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin. [electronic resource] - Journal of medicinal chemistry May 1997 - 1731-7 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
0022-2623
10.1021/jm960864o doi
Animals
Antineoplastic Agents--chemical synthesis
Cell Division--drug effects
Computer Simulation
Crystallography, X-Ray
Enzyme Inhibitors--chemical synthesis
Guanosine Triphosphate--metabolism
Humans
IMP Dehydrogenase--antagonists & inhibitors
Inosine Monophosphate--metabolism
Leukemia--pathology
Lymphoma--pathology
Magnetic Resonance Spectroscopy
Mice
Models, Molecular
Molecular Structure
Neoplasms--pathology
Organoselenium Compounds--chemical synthesis
Ribavirin--analogs & derivatives
Ribonucleosides--chemical synthesis
Tumor Cells, Cultured