Ifosfamide metabolite chloroacetaldehyde causes renal dysfunction in vivo.

Springate, J E

Ifosfamide metabolite chloroacetaldehyde causes renal dysfunction in vivo. [electronic resource] - Journal of applied toxicology : JAT - 75-9 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

0260-437X

10.1002/(sici)1099-1263(199701)17:1<75::aid-jat397>3.0.co;2-c doi


Acetaldehyde--analogs & derivatives
Animals
Antineoplastic Agents, Alkylating--metabolism
Dose-Response Relationship, Drug
Glutathione--metabolism
Glycosuria--urine
Ifosfamide--metabolism
Kidney--drug effects
Kidney Diseases--chemically induced
Lipid Peroxidation
Male
Mesna--therapeutic use
Proteinuria--urine
Rats
Rats, Sprague-Dawley
Sodium--urine