Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo.

Tsiang, M

Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo. [electronic resource] - Biochemistry Dec 1996 - 16449-57 p. digital

Publication Type: Journal Article

0006-2960

10.1021/bi9616108 doi


Animals
Anticoagulants--pharmacology
Blood Coagulation--drug effects
Drug Evaluation, Preclinical
Fibrinogen--metabolism
Half-Life
Humans
Kinetics
Macaca fascicularis
Models, Molecular
Mutagenesis, Site-Directed
Platelet Activation--drug effects
Protein C--metabolism
Protein Conformation
Protein Engineering
Substrate Specificity
Thrombin--genetics