Bioreductive activation of a series of analogues of 5-aziridinyl-3-hydroxymethyl-1-methyl-2-[1H-indole-4, 7-dione] prop-beta-en-alpha-ol (EO9) by human DT-diaphorase.

Phillips, R M

Bioreductive activation of a series of analogues of 5-aziridinyl-3-hydroxymethyl-1-methyl-2-[1H-indole-4, 7-dione] prop-beta-en-alpha-ol (EO9) by human DT-diaphorase. [electronic resource] - Biochemical pharmacology Dec 1996 - 1711-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0006-2952

10.1016/s0006-2952(96)00521-7 doi


Antineoplastic Agents--metabolism
Aziridines--metabolism
Biotransformation
Cell Survival--drug effects
DNA--metabolism
Humans
Indolequinones
Indoles--metabolism
Kinetics
NAD(P)H Dehydrogenase (Quinone)--metabolism
Structure-Activity Relationship
Tumor Cells, Cultured