Cardiovascular characterization of pyrrolo[2,1-d][1,5]benzothiazepine derivatives binding selectively to the peripheral-type benzodiazepine receptor (PBR): from dual PBR affinity and calcium antagonist activity to novel and selective calcium entry blockers.
Campiani, G
Cardiovascular characterization of pyrrolo[2,1-d][1,5]benzothiazepine derivatives binding selectively to the peripheral-type benzodiazepine receptor (PBR): from dual PBR affinity and calcium antagonist activity to novel and selective calcium entry blockers. [electronic resource] - Journal of medicinal chemistry Jul 1996 - 2922-38 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
0022-2623
10.1021/jm960162z doi
Animals
Atrial Function
Binding, Competitive
Calcium Channel Blockers--chemical synthesis
Calcium Channels--metabolism
Cardiovascular System--drug effects
Cerebral Cortex--metabolism
Depression, Chemical
Female
Guinea Pigs
Heart Rate--drug effects
Male
Models, Molecular
Myocardial Contraction--drug effects
Myocardium--metabolism
Pyrroles--chemical synthesis
Rats
Rats, Sprague-Dawley
Receptors, GABA-A--metabolism
Structure-Activity Relationship
Thiazepines--chemical synthesis
Cardiovascular characterization of pyrrolo[2,1-d][1,5]benzothiazepine derivatives binding selectively to the peripheral-type benzodiazepine receptor (PBR): from dual PBR affinity and calcium antagonist activity to novel and selective calcium entry blockers. [electronic resource] - Journal of medicinal chemistry Jul 1996 - 2922-38 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
0022-2623
10.1021/jm960162z doi
Animals
Atrial Function
Binding, Competitive
Calcium Channel Blockers--chemical synthesis
Calcium Channels--metabolism
Cardiovascular System--drug effects
Cerebral Cortex--metabolism
Depression, Chemical
Female
Guinea Pigs
Heart Rate--drug effects
Male
Models, Molecular
Myocardial Contraction--drug effects
Myocardium--metabolism
Pyrroles--chemical synthesis
Rats
Rats, Sprague-Dawley
Receptors, GABA-A--metabolism
Structure-Activity Relationship
Thiazepines--chemical synthesis