Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract.

Goldberg, Y P

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. [electronic resource] - Nature genetics Aug 1996 - 442-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1061-4036

10.1038/ng0896-442 doi


Animals
Apoptosis
Caspase 3
Caspases
Cell Line
Chlorocebus aethiops
Cysteine Endopeptidases--metabolism
Humans
Huntingtin Protein
Huntington Disease--physiopathology
Kinetics
Nerve Tissue Proteins--metabolism
Nuclear Proteins--metabolism
Peptides--chemistry
Recombinant Proteins
Structure-Activity Relationship
Substrate Specificity
Transfection
Trinucleotide Repeats