The squalestatins: inhibitors of squalene synthase. Enzyme inhibitory activities and in vivo evaluation of C3-modified analogues.

Procopiou, P A

The squalestatins: inhibitors of squalene synthase. Enzyme inhibitory activities and in vivo evaluation of C3-modified analogues. [electronic resource] - Journal of medicinal chemistry Mar 1996 - 1413-22 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm950893j doi


Animals
Anticholesteremic Agents--chemical synthesis
Bridged Bicyclo Compounds, Heterocyclic--chemistry
Callithrix--metabolism
Cholesterol--biosynthesis
Enzyme Inhibitors--chemical synthesis
Esters--chemical synthesis
Farnesyl-Diphosphate Farnesyltransferase--antagonists & inhibitors
Microsomes, Liver--enzymology
Molecular Structure
Rats
Tricarboxylic Acids--chemistry