Mapping the aspartic acid binding site of Escherichia coli asparagine synthetase B using substrate analogs.
Parr, I B
Mapping the aspartic acid binding site of Escherichia coli asparagine synthetase B using substrate analogs. [electronic resource] - Journal of medicinal chemistry Jun 1996 - 2367-78 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0022-2623
10.1021/jm9601009 doi
Alkylation
Antineoplastic Agents--chemistry
Asparagine--biosynthesis
Aspartate-Ammonia Ligase--antagonists & inhibitors
Aspartic Acid--analogs & derivatives
Bacterial Proteins--antagonists & inhibitors
Binding Sites
Drug Design
Enzyme Inhibitors--chemical synthesis
Escherichia coli--enzymology
Glutamine--metabolism
Humans
Isoenzymes--antagonists & inhibitors
Kinetics
Molecular Conformation
Molecular Structure
Neoplasm Proteins--antagonists & inhibitors
Precursor Cell Lymphoblastic Leukemia-Lymphoma--drug therapy
Protein Binding
Stereoisomerism
Structure-Activity Relationship
Substrate Specificity
Mapping the aspartic acid binding site of Escherichia coli asparagine synthetase B using substrate analogs. [electronic resource] - Journal of medicinal chemistry Jun 1996 - 2367-78 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0022-2623
10.1021/jm9601009 doi
Alkylation
Antineoplastic Agents--chemistry
Asparagine--biosynthesis
Aspartate-Ammonia Ligase--antagonists & inhibitors
Aspartic Acid--analogs & derivatives
Bacterial Proteins--antagonists & inhibitors
Binding Sites
Drug Design
Enzyme Inhibitors--chemical synthesis
Escherichia coli--enzymology
Glutamine--metabolism
Humans
Isoenzymes--antagonists & inhibitors
Kinetics
Molecular Conformation
Molecular Structure
Neoplasm Proteins--antagonists & inhibitors
Precursor Cell Lymphoblastic Leukemia-Lymphoma--drug therapy
Protein Binding
Stereoisomerism
Structure-Activity Relationship
Substrate Specificity