Pharmacology of L-754,142, a highly potent, orally active, nonpeptidyl endothelin antagonist.

Williams, D L

Pharmacology of L-754,142, a highly potent, orally active, nonpeptidyl endothelin antagonist. [electronic resource] - The Journal of pharmacology and experimental therapeutics Dec 1995 - 1518-26 p. digital

Publication Type: Journal Article

0022-3565


Acetamides--pharmacokinetics
Administration, Oral
Animals
Biological Availability
Blood Pressure--drug effects
CHO Cells
Cricetinae
Endothelin Receptor Antagonists
Endothelins--antagonists & inhibitors
Ferrets
Humans
Hydrolysis
In Vitro Techniques
Male
Mice
Muscle Contraction--drug effects
Muscle, Smooth, Vascular--drug effects
Phosphatidylinositols--metabolism
Rabbits
Rats
Rats, Sprague-Dawley
Receptors, Endothelin--metabolism