Preparation of substituted N-phenyl-4-aryl-2-pyrimidinamines as mediator release inhibitors.

Paul, R

Preparation of substituted N-phenyl-4-aryl-2-pyrimidinamines as mediator release inhibitors. [electronic resource] - Journal of medicinal chemistry Sep 1993 - 2716-25 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm00071a002 doi


Animals
Basophils--drug effects
Female
Histamine Antagonists--chemical synthesis
Humans
Imidazoles--chemical synthesis
Lethal Dose 50
Macaca mulatta
Male
Mice
Passive Cutaneous Anaphylaxis--drug effects
Pyrimidines--chemical synthesis
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship