Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation.

Rao, C M

Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. [electronic resource] - Journal of medicinal chemistry Sep 1993 - 2614-20 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0022-2623

10.1021/jm00070a004 doi


Amino Acid Sequence
Aspartic Acid Endopeptidases--antagonists & inhibitors
Binding Sites
Cathepsin D--antagonists & inhibitors
Cathepsin E
Cathepsins--antagonists & inhibitors
Computer Simulation
Dipeptides--chemistry
Humans
Models, Molecular
Molecular Sequence Data
Molecular Structure
Morpholines--chemistry
Pepsin A--antagonists & inhibitors
Protease Inhibitors--chemistry
Renin--antagonists & inhibitors
Structure-Activity Relationship