Inhibition of inositol 1,4,5-trisphosphate 5-phosphatase by micromolar concentrations of disulfiram and its analogues.

Fowler, C J

Inhibition of inositol 1,4,5-trisphosphate 5-phosphatase by micromolar concentrations of disulfiram and its analogues. [electronic resource] - The Biochemical journal Feb 1993 - 853-9 p. digital

Publication Type: Comparative Study; Journal Article

0264-6021

10.1042/bj2890853 doi


Animals
Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide--pharmacology
Calcium--metabolism
Calcium Channels
Cattle
Cell Compartmentation--drug effects
Cells, Cultured
Cerebellum--metabolism
Disulfiram--analogs & derivatives
Dose-Response Relationship, Drug
Hydrolysis
Inositol 1,4,5-Trisphosphate--metabolism
Inositol 1,4,5-Trisphosphate Receptors
Inositol Polyphosphate 5-Phosphatases
Membranes--metabolism
Phosphatidylinositols--metabolism
Phosphoric Monoester Hydrolases--antagonists & inhibitors
Piperazines--pharmacology
Piperidines--pharmacology
Pituitary Gland--enzymology
Rats
Receptors, Cell Surface--metabolism
Receptors, Cytoplasmic and Nuclear
Thyrotropin-Releasing Hormone--pharmacology