The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide.

Stein, P D

The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide. [electronic resource] - Journal of medicinal chemistry Feb 1994 - 329-31 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm00029a001 doi


Animals
Antihypertensive Agents--chemical synthesis
Cell Line
Dansyl Compounds--chemical synthesis
Endothelin Receptor Antagonists
Endothelins--metabolism
Hypertension--drug therapy
Molecular Structure
Muscle, Smooth, Vascular--drug effects
Rabbits
Rats
Structure-Activity Relationship