Inhibitors of acyl-CoA:cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 8. Incorporation of amide or amine functionalities into a series of disubstituted ureas and carbamates. Effects on ACAT inhibition in vitro and efficacy in vivo.

O'Brien, P M

Inhibitors of acyl-CoA:cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 8. Incorporation of amide or amine functionalities into a series of disubstituted ureas and carbamates. Effects on ACAT inhibition in vitro and efficacy in vivo. [electronic resource] - Journal of medicinal chemistry Jun 1994 - 1810-22 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm00038a010 doi


Amides--chemistry
Amines--chemistry
Animals
Anticholesteremic Agents--chemistry
Carbamates--chemistry
Disease Models, Animal
Rabbits
Rats
Sterol O-Acyltransferase--antagonists & inhibitors
Structure-Activity Relationship
Urea--chemistry