Synthesis and molecular modeling of 1-phenyl-1,2,3,4-tetrahydroisoquinolines and related 5,6,8,9-tetrahydro-13bH-dibenzo[a,h]quinolizines as D1 dopamine antagonists.

Minor, D L

Synthesis and molecular modeling of 1-phenyl-1,2,3,4-tetrahydroisoquinolines and related 5,6,8,9-tetrahydro-13bH-dibenzo[a,h]quinolizines as D1 dopamine antagonists. [electronic resource] - Journal of medicinal chemistry Dec 1994 - 4317-28 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.

0022-2623

10.1021/jm00051a008 doi


Animals
Benzazepines--metabolism
Binding, Competitive
Cell Membrane--metabolism
Chemical Phenomena
Chemistry, Physical
Computer Simulation
Corpus Striatum--metabolism
Electrochemistry
Isoquinolines--chemical synthesis
Male
Models, Molecular
Molecular Conformation
Quinolizines--chemical synthesis
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D1--agonists
Regression Analysis
Structure-Activity Relationship