Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs.

Schinkel, A H

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. [electronic resource] - Cell May 1994 - 491-502 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0092-8674

10.1016/0092-8674(94)90212-7 doi


ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Blood-Brain Barrier--drug effects
Capillaries--chemistry
Carrier Proteins--analysis
Drug Resistance--genetics
Epithelial Cells
Female
Intestine, Small--chemistry
Ivermectin--blood
Male
Membrane Glycoproteins--analysis
Mice
Mice, Knockout--genetics
Mutagenesis, Insertional
RNA, Messenger--analysis
Tissue Distribution
Vinblastine--pharmacokinetics