Conformationally constrained o-tolylpiperazine camphorsulfonamide oxytocin antagonists. Structural modifications that provide high receptor affinity and suggest a bioactive conformation.
Williams, P D
Conformationally constrained o-tolylpiperazine camphorsulfonamide oxytocin antagonists. Structural modifications that provide high receptor affinity and suggest a bioactive conformation. [electronic resource] - Bioorganic & medicinal chemistry Sep 1994 - 971-85 p. digital
Publication Type: Comparative Study; Journal Article
0968-0896
10.1016/s0968-0896(00)82046-5 doi
Amino Acid Sequence
Animals
Camphor--analogs & derivatives
Female
Humans
Kidney--metabolism
Kinetics
Liver--metabolism
Male
Models, Molecular
Molecular Conformation
Molecular Sequence Data
Oxytocin--antagonists & inhibitors
Piperazines--chemical synthesis
Rats
Receptors, Oxytocin--antagonists & inhibitors
Receptors, Vasopressin--drug effects
Structure-Activity Relationship
Sulfonamides--chemical synthesis
Tritium
Uterine Contraction--drug effects
Uterus--metabolism
Conformationally constrained o-tolylpiperazine camphorsulfonamide oxytocin antagonists. Structural modifications that provide high receptor affinity and suggest a bioactive conformation. [electronic resource] - Bioorganic & medicinal chemistry Sep 1994 - 971-85 p. digital
Publication Type: Comparative Study; Journal Article
0968-0896
10.1016/s0968-0896(00)82046-5 doi
Amino Acid Sequence
Animals
Camphor--analogs & derivatives
Female
Humans
Kidney--metabolism
Kinetics
Liver--metabolism
Male
Models, Molecular
Molecular Conformation
Molecular Sequence Data
Oxytocin--antagonists & inhibitors
Piperazines--chemical synthesis
Rats
Receptors, Oxytocin--antagonists & inhibitors
Receptors, Vasopressin--drug effects
Structure-Activity Relationship
Sulfonamides--chemical synthesis
Tritium
Uterine Contraction--drug effects
Uterus--metabolism