The complex of FK506-binding protein 12 and FK506 inhibits calcineurin phosphatase activity and IgE activation-induced cytokine transcripts, but not exocytosis, in mouse mast cells.

Fruman, D A

The complex of FK506-binding protein 12 and FK506 inhibits calcineurin phosphatase activity and IgE activation-induced cytokine transcripts, but not exocytosis, in mouse mast cells. [electronic resource] - Journal of immunology (Baltimore, Md. : 1950) Feb 1995 - 1846-51 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0022-1767


Animals
Calcineurin
Calmodulin-Binding Proteins--antagonists & inhibitors
Carrier Proteins--metabolism
Cell Line, Transformed
Cytoplasmic Granules--drug effects
DNA-Binding Proteins--metabolism
Exocytosis--drug effects
Gene Expression Regulation--drug effects
Heat-Shock Proteins--metabolism
Immunoglobulin E--immunology
Interleukin-6--biosynthesis
Mast Cells--drug effects
Mice
Mice, Inbred BALB C
Phosphoprotein Phosphatases--antagonists & inhibitors
Recombinant Fusion Proteins--metabolism
T-Lymphocytes--immunology
Tacrolimus--metabolism
Tacrolimus Binding Proteins
Transfection
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha--biosynthesis
beta-N-Acetylhexosaminidases--metabolism