Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit.
Jonckheere, H
Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit. [electronic resource] - The Journal of biological chemistry Oct 1994 - 25255-8 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
0021-9258
Antiviral Agents--chemistry
Base Sequence
Benzodiazepines--pharmacology
Binding Sites--genetics
Deoxyguanine Nucleotides--pharmacology
Dideoxynucleotides
Drug Resistance--genetics
Escherichia coli--genetics
HIV Reverse Transcriptase
Imidazoles--pharmacology
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Protein Conformation
RNA-Directed DNA Polymerase--genetics
Recombinant Proteins--metabolism
Reverse Transcriptase Inhibitors
Sequence Analysis, DNA
Spiro Compounds
Thymidine--analogs & derivatives
Uridine--analogs & derivatives
Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit. [electronic resource] - The Journal of biological chemistry Oct 1994 - 25255-8 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
0021-9258
Antiviral Agents--chemistry
Base Sequence
Benzodiazepines--pharmacology
Binding Sites--genetics
Deoxyguanine Nucleotides--pharmacology
Dideoxynucleotides
Drug Resistance--genetics
Escherichia coli--genetics
HIV Reverse Transcriptase
Imidazoles--pharmacology
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Protein Conformation
RNA-Directed DNA Polymerase--genetics
Recombinant Proteins--metabolism
Reverse Transcriptase Inhibitors
Sequence Analysis, DNA
Spiro Compounds
Thymidine--analogs & derivatives
Uridine--analogs & derivatives